Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans

Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans

Blog Article

Selectins constitute a family of oligosaccharide binding proteins that play critical roles in regulating the trafficking of leukocytes.In T cells, L-selectin (CD62L) controls the capacity for naive and memory T cells to actively survey peripheral lymph nodes, whereas P- and E-selectin capture activated T cells on inflamed vascular endothelium to initiate extravasation into non-lymphoid tissues.The capacity for T cells to Custom Mug interact with all of these selectins is dependent on the enzymatic synthesis of complex O-glycans, and thus, this protein modification plays an indispensable role in regulating the distribution and homing of both naive and previously activated T cells in vivo.In contrast to neutrophils, O-glycan synthesis is highly dynamic in T cell populations and is largely controlled by extracellular stimuli such as antigen recognition or signaling though cytokine receptors.

Herein, we review Pastry Tips the basic principles of enzymatic synthesis of complex O-glycans, discuss tools and reagents for studying this type of protein modification and highlight our current understanding of how O-glycan synthesis is regulated and subsequently impacts the trafficking potential of diverse T cell populations.